Eliminating Mitochondrial DNA from Sperm

Most eukaryotes show uniparental inheritance of mitochondrial DNA (mtDNA). In this issue of Developmental Cell, DeLuca and O'Farrell (2012) show that active elimination of mtDNA during sperm development in Drosophila ensures that mature spermatozoa are devoid of DNA

Ethical Implications in AI-Powered Trend Research Platforms

The manuscript discusses the limitations of applying AI in trend research platforms for the fashion system. This analysis intends to take a position within the emergent research topic of AI. Considering its ethical implications, we explore the opportunities of implementing AI to support trend research from a design-oriented perspective, realising the relationship between fashion and trends, which is central in shaping the future. Examples of AI-powered trend platforms evidence how valuable their insights are for strategic innovation. The analysis focuses on platforms that provide tailored services using AI and expert interpretation. Virtue ethics of technology serves as a useful framework to examine this topic, proposing a new set of virtues that respond to technology’s shaping of behaviour and its disadvantages. The risks of applying AI are many-fold; the consequences perpetuate power imbalances and social inequality. Proposing guidelines for enabling a responsible practice explores how to forge ethics into AI, creating a pluralised practice

Stabilizing Superconductivity in Nanowires by Coupling to Dissipative Environments

We present a theory for a finite-length superconducting nanowire coupled to an environment. We show that in the absence of dissipation quantum phase slips always destroy superconductivity, even at zero temperature. Dissipation stabilizes the superconducting phase. We apply this theory to explain the "anti-proximity effect" recently seen by Tian et. al. in Zinc nanowires.Comment: 4 pages, 3 figure

Supermassive black hole seeds from sub-keV dark matter

Quasars observed at redshifts $z\sim 6-7.5$ are powered by supermassive black holes which are too large to have grown from early stellar remnants without efficient super-Eddington accretion. A proposal for alleviating this tension is for dust and metal-free gas clouds to have undergone a process of direct collapse, producing black hole seeds of mass $M_\textrm{seed}\sim10^5 M_\odot$ around redshift $z \sim 17$. For direct collapse to occur, a large flux of UV photons must exist to photodissociate molecular hydrogen, allowing the gas to cool slowly and avoid fragmentation. We investigate the possibility of sub-keV mass dark matter decaying or annihilating to produce the UV flux needed to cause direct collapse. We find that annihilating dark matter with a mass in the range of $13.6 \textrm{ eV} \le m_{dm} \le 20 \textrm{ eV}$ can produce the required flux while avoiding existing constraints. A non-thermally produced dark matter particle which comprises the entire dark matter abundance requires a thermally averaged cross section of $\langle\sigma v \rangle \sim 10^{-35}$ cm$^3/$s. Alternatively, the flux could originate from a thermal relic which comprises only a fraction $\sim10^{-9}$ of the total dark matter density. Decaying dark matter models which are unconstrained by independent astrophysical observations are unable to sufficiently suppress molecular hydrogen, except in gas clouds embedded in dark matter halos which are larger, cuspier, or more concentrated than current simulations predict. Lastly, we explore how our results could change with the inclusion of full three-dimensional effects. Notably, we demonstrate that if the $\mathrm{H}_2$ self-shielding is less than the conservative estimate used in this work, the range of both annihilating and decaying dark matter models which can cause direct collapse is significantly increased.Comment: 24 pages, 9 figures. Updated to match published versio

The [4+2] cycloaddition of donor-acceptor cyclobutanes and nitrosoarenes.

The Yb(OTf)3 catalyzed [4+2] cycloaddition between donor-acceptor cyclobutanes and nitrosoarenes is disclosed. This method facilitates the synthesis of tetrahydro-1,2-oxazines in good to excellent yields as single diastereomers. Except for a few electron-deficient nitrosoarenes, excellent regioselectivity was observed throughout these studies

Fluxes, Gaugings and Gaugino Condensates

Based on the correspondence between the N = 1 superstring compactifications with fluxes and the N = 4 gauged supergravities, we study effective N = 1 four-dimensional supergravity potentials arising from fluxes and gaugino condensates in the framework of orbifold limits of (generalized) Calabi-Yau compactifications. We give examples in heterotic and type II orientifolds in which combined fluxes and condensates lead to vacua with small supersymmetry breaking scale. We clarify the respective roles of fluxes and condensates in supersymmetry breaking, and analyze the scaling properties of the gravitino mass.Comment: 17 pages, C

Influences on Affiliate HRM Systems in Japanese MNCs in Southeast Asia

Using data from 160 Asian affiliates of American and Japanese MNCs, this paper explores the determinants of whether MNCs transfer their parent company HRM systems overseas or adopt local practices. We find that demographic predictor variables which have often been found in previous studies to predict similarity are relatively unimportant while perceived HRM competence of the MNC is an important determinant of HRM transfer

A cyclopentadienyl functionalized silylene-a flexible ligand for Si- And C-coordination

The synthesis of a 1,2,3,4-tetramethylcyclopentadienyl (Cp$^{4}$) substituted four-membered N-heterocyclic silylene [{PhC(NtBu) $_{2}$}Si(C$_{5}$Me$_{4}$H)] is reported first. Then, selected reactions with transition metal and a calcium precursor are shown. The proton of the Cp$_{4}$-unit is labile. This results in two different reaction pathways: (1) deprotonation and (2) rearrangement reactions. Deprotonation was achieved by the reaction of [{PhC(NtBu) $_{2}$}Si(C$_{5}$Me$_{4}$H)] with suitable zinc precursors. Rearrangement to [{PhC(NtBu) $_{2}$}(C$_{5}$Me$_{4}$)SiH], featuring a formally tetravalent silicon R$_{2}$CSi(R′)-H unit, was observed when the proton of the Cp$^{4}$ ring was shifted from the Cp$^{4}$-ring to the silylene in the presence of a Lewis acid. This allows for the coordination of the Cp$^{4}$-ring to a calcium compound. Furthermore, upon reaction with transition metal dimers [MCl(cod)] $_{2}$ (M = Rh, Ir; cod = 1,5-cyclooctadiene) the proton stays at the Cp$^{4}$-ring and the silylene reacts as a sigma donor, which breaks the dimeric structure of the precursors